Description & Usage

Phenylpropanolamine (PPA) is used to help treat urinary incontinence in spayed dogs due to weakened muscles of the urethral sphincter (urethral sphincter hypotonus). Phenylpropanolamine ER (Extended-Release) tablets provide a steady absorption while maintaining a safe and effective concentration of medication as a single daily dose.

Precautions & Side Effects

For oral use in dogs only. Not for human use. Keep out of reach of children. If accidentally ingested by humans, contact a physician immediately. The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In some cases death, including euthanasia has been reported. Sudden death was sometimes preceded by vocalization or collapse.Contact your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN^® chewable tablets or PROIN ER™ tablets.

PROIN ER™ may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure. The safe use of PROIN^® and PROIN ER™ in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated. Contact your veterinarian if you notice restlessness or irritability, loss of appetite, the incontinence persists or worsens, or any other unusual signs.